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TOLRESTAT

Product Name
TOLRESTAT
CAS No.
82964-04-3
Chemical Name
TOLRESTAT
Synonyms
CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
CBNumber
CB2174693
Molecular Formula
C16H14F3NO3S
Formula Weight
357.35
MOL File
82964-04-3.mol
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TOLRESTAT Property

Melting point:
164-165°
Boiling point:
498.1±55.0 °C(Predicted)
Density 
1.399±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
powder
pka
3.49±0.10(Predicted)
color 
white to beige
CAS DataBase Reference
82964-04-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1573
Product name
Tolrestat
Purity
≥98% (HPLC)
Packaging
5MG
Price
$117
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1573
Product name
Tolrestat
Purity
≥98% (HPLC)
Packaging
25MG
Price
$478
Updated
2023/06/20
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
1mg
Price
$32
Updated
2024/03/01
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TOLRESTAT Chemical Properties,Usage,Production

Description

Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.

Description

Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.

Originator

American Home Products (USA)

Uses

Tolrestat is an aldose reductase inhibitor.

Uses

Alredase (Wyeth-Ayerst).

Definition

ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.

brand name

Alredase

Biochem/physiol Actions

Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.

TOLRESTAT Preparation Products And Raw materials

Raw materials

Phosphorus pentasulfide 1-Naphthoic acid Glycine methyl ester hydrochloride 1,5-DIMETHYLNAPHTHALENE Sarcosine

Preparation Products

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TOLRESTAT Suppliers

China 72 Europe 2 France 1 Germany 1 India 1 United Kingdom 2 United States 18 Global 97
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
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70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
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65

82964-04-3, TOLRESTATRelated Search:

Naphthalene Naftifine Stearic acid Anthracene Acetonitrile Oxalic acid dihydrate Benzyl alcohol Tolrestat S-oxide alpha,alpha,alpha-Trifluoro-o-cresol TOLRESTAT 2-(TRIFLUOROMETHYL)ANISOLE N-methylthiobenzamide 1-TRIFLUOROMETHYL-NAPHTHALENE

  • TOLRESTAT
  • TOLRESTAT(FORR&DONLY)
  • Alredase
  • AY-27773
  • Lorestat
  • N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine
  • Aldredase
  • N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine
  • [(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid
  • 2-(6-Methoxy-N-Methyl-5-(trifluoroMethyl)naphthalene-1-carbothioaMido)acetic acid
  • Tolrestatin
  • TolrestattolrestattolrestatTolrestat
  • CS-148
  • Tolrestat, AY 27773
  • AY-27773;AY 27773; AY27773
  • Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-
  • TOLRESTAT USP/EP/BP
  • Inhibitor,inhibit,Tolrestat,AY 27773,Aldose Reductase,AY27773
  • 82964-04-3